Reactome Pathway Database

Schema > Reaction > Entries

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro Show undefined attributes

catalystActivity

[CatalystActivity:10426621] pyrroline-5-carboxylate reductase activity of PYCR1 decamer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10426623

displayName PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

eventOf

[Pathway:R-SSC-8964539] Glutamate and glutamine metabolism - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) - Sus scrofa

inferredFrom

[Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro
1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-70664

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-8964539] Glutamate and glutamine metabolism

(precedingEvent)

[Reaction:R-SSC-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)

(inferredTo)

[Reaction:R-HSA-70664] PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro

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