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Schema
>
Polymer
>
Entries
K63polyUb [cytosol]
Show undefined attributes
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compartment
[Compartment:70101] cytosol
componentOf
[Complex:R-SSC-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] - Sus scrofa
[Complex:R-SSC-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] - Sus scrofa
[Complex:R-SSC-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] - Sus scrofa
[Complex:R-SSC-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] - Sus scrofa
[Complex:R-SSC-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] - Sus scrofa
[Complex:R-SSC-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane] - Sus scrofa
[Complex:R-SSC-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Sus scrofa
[Complex:R-SSC-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Sus scrofa
[Complex:R-SSC-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane] - Sus scrofa
[Complex:R-SSC-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] - Sus scrofa
[Complex:R-SSC-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] - Sus scrofa
consumedByEvent
[BlackBoxEvent:R-SSC-5696547] STAMBPL1 is a deubiquitinase - Sus scrofa
[Reaction:R-SSC-5691431] PSMD14 cleaves K63-linked ubiquitin - Sus scrofa
[Reaction:R-SSC-5688797] ATXN3 family cleave Ub chains - Sus scrofa
[BlackBoxEvent:R-SSC-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Sus scrofa
[Reaction:R-SSC-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
- Sus scrofa
[Reaction:R-SSC-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Sus scrofa
[Reaction:R-SSC-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Sus scrofa
[Reaction:R-SSC-9931430] MIB2-mediated K63-ubiquitination of CD274 - Sus scrofa
[BlackBoxEvent:R-SSC-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Sus scrofa
[Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa
[Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa
[Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa
[BlackBoxEvent:R-SSC-5607756] TRAF6 oligomer autoubiquitinates - Sus scrofa
[BlackBoxEvent:R-SSC-2730904] Auto-ubiquitination of TRAF6 - Sus scrofa
[Reaction:R-SSC-937050] Pellino ubiquitinates hp-IRAK1 - Sus scrofa
[Reaction:R-SSC-937050] Pellino ubiquitinates hp-IRAK1 - Sus scrofa
[Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Sus scrofa
[Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Sus scrofa
[BlackBoxEvent:R-SSC-202534] Ubiquitination of NEMO by TRAF6 - Sus scrofa
[BlackBoxEvent:R-SSC-5607757] K63polyUb-TRAF6 ubiquitinates TAK1 - Sus scrofa
[Reaction:R-SSC-202453] Auto-ubiquitination of TRAF6 - Sus scrofa
[Reaction:R-SSC-202453] Auto-ubiquitination of TRAF6 - Sus scrofa
[Reaction:R-SSC-202453] Auto-ubiquitination of TRAF6 - Sus scrofa
[Reaction:R-SSC-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Sus scrofa
[Reaction:R-SSC-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Sus scrofa
[Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa
[Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa
[Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex - Sus scrofa
created
[InstanceEdit:10424722] Weiser, Joel, 2025年08月27日
dbId
10437517
displayName
K63polyUb [cytosol]
inDisease
false
inferredFrom
[Polymer:R-HSA-6783297] Short K63polyUb [cytosol] - Homo sapiens
[Polymer:R-HSA-450152] K63polyUb [cytosol] - Homo sapiens
maxDepth
4
memberOf
[DefinedSet:R-SSC-5689096] PolyUb [cytosol] - Sus scrofa
name
K63polyUb
producedByEvent
[Reaction:R-SSC-5688797] ATXN3 family cleave Ub chains - Sus scrofa
[Polymerisation:R-SSC-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Sus scrofa
[Polymerisation:R-SSC-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Sus scrofa
[Polymerisation:R-SSC-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Sus scrofa
[Reaction:R-SSC-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 - Sus scrofa
[Reaction:R-SSC-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 - Sus scrofa
[Reaction:R-SSC-6781779] USP13 deubiquitinates BECN1,USP10 - Sus scrofa
[Reaction:R-SSC-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Sus scrofa
[Reaction:R-SSC-6781814] USP19 deubiquitinates RNF123 - Sus scrofa
[Reaction:R-SSC-5691439] BRISC complex deubiquitinates NLRP3 - Sus scrofa
repeatedUnit
[DefinedSet:R-SSC-450143] K63-Ub [cytosol]
schemaClass
Polymer
species
[Species:49633] Sus scrofa
stId
R-SSC-450152
summation
[Summation:9965818] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Referrals
(output)
[Reaction:R-SSC-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
[Reaction:R-SSC-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
[Reaction:R-SSC-6781779] USP13 deubiquitinates BECN1,USP10
[Reaction:R-SSC-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
[Reaction:R-SSC-6781814] USP19 deubiquitinates RNF123
[Reaction:R-SSC-5691439] BRISC complex deubiquitinates NLRP3
[Reaction:R-SSC-5688797] ATXN3 family cleave Ub chains
[Polymerisation:R-SSC-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
[Polymerisation:R-SSC-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
[Polymerisation:R-SSC-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains
(input)
[BlackBoxEvent:R-SSC-5696547] STAMBPL1 is a deubiquitinase
[Reaction:R-SSC-5691431] PSMD14 cleaves K63-linked ubiquitin
[Reaction:R-SSC-5688797] ATXN3 family cleave Ub chains
[Reaction:R-SSC-9931430] MIB2-mediated K63-ubiquitination of CD274
[BlackBoxEvent:R-SSC-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
[BlackBoxEvent:R-SSC-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1
[Reaction:R-SSC-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
[Reaction:R-SSC-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
[BlackBoxEvent:R-SSC-202534] Ubiquitination of NEMO by TRAF6
[BlackBoxEvent:R-SSC-5607757] K63polyUb-TRAF6 ubiquitinates TAK1
[BlackBoxEvent:R-SSC-5607756] TRAF6 oligomer autoubiquitinates
[BlackBoxEvent:R-SSC-2730904] Auto-ubiquitination of TRAF6
[Reaction:R-SSC-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex
[Reaction:R-SSC-202453] Auto-ubiquitination of TRAF6
[Reaction:R-SSC-937050] Pellino ubiquitinates hp-IRAK1
[Reaction:R-SSC-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
[Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
[Reaction:R-SSC-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex
(inferredTo)
[Polymer:R-HSA-6783297] Short K63polyUb [cytosol]
[Polymer:R-HSA-450152] K63polyUb [cytosol]
(hasComponent)
[Complex:R-SSC-975171] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane]
[Complex:R-SSC-975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]
[Complex:R-SSC-8948017] UBE2N:UBE2V1:K63polyUb [cytosol]
[Complex:R-SSC-936946] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane]
[Complex:R-SSC-936954] activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane]
[Complex:R-SSC-9645449] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
[Complex:R-SSC-9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
[Complex:R-SSC-937008] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [plasma membrane]
[Complex:R-SSC-936953] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [plasma membrane]
[Complex:R-SSC-847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol]
[Complex:R-SSC-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(hasMember)
[DefinedSet:R-SSC-5689096] PolyUb [cytosol]
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