Reactome Pathway Database

Schema > Reaction > Entries

12S-HpETE is reduced to 12S-HETE by GPX1/2/4 Show undefined attributes

catalystActivity

[CatalystActivity:10481986] glutathione peroxidase activity of GPX1/2/4 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10482016

displayName 12S-HpETE is reduced to 12S-HETE by GPX1/2/4

eventOf

[Pathway:R-SSC-2142712] Synthesis of 12-eicosatetraenoic acid derivatives - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

12S-HpETE is reduced to 12S-HETE by GPX1/2/4
(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

output

precedingEvent

[Reaction:R-SSC-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-2161999

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-2142712] Synthesis of 12-eicosatetraenoic acid derivatives

(inferredTo)

[Reaction:R-HSA-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4

© 2025 Reactome

Cite Us!