Reactome Pathway Database

Schema > Reaction > Entries

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate Show undefined attributes

catalystActivity

[CatalystActivity:10444189] methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10444227

displayName 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

eventOf

[Pathway:R-SSC-196757] Metabolism of folate and pterines - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Sus scrofa

inferredFrom

[Reaction:R-HSA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

output

[SimpleEntity:R-ALL-111353] 10-formyl-THFPG [cytosol]

precedingEvent

[Reaction:R-SSC-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-200740

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-196757] Metabolism of folate and pterines

(precedingEvent)

[Reaction:R-SSC-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

(inferredTo)

[Reaction:R-HSA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

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