Reactome Pathway Database

Schema > Reaction > Entries

PTEN dephosphorylates PIP3 Show undefined attributes

catalystActivity

[CatalystActivity:10443818] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]

category transition

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10443820

displayName PTEN dephosphorylates PIP3

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Sus scrofa
[Reaction:R-SSC-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Sus scrofa
[Reaction:R-SSC-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Sus scrofa
[Reaction:R-SSC-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Sus scrofa
[Reaction:R-SSC-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Sus scrofa

goBiologicalProcess [GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferredFrom

[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PTEN dephosphorylates PIP3
PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-199456

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)

(hasEvent)

(inferredTo)

[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3

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