Reactome Pathway Database

Schema > Reaction > Entries

Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines Show undefined attributes

catalystActivity

[CatalystActivity:10474534] procollagen-proline 4-dioxygenase activity of Prolyl 4-hydroxylases [endoplasmic reticulum lumen]

category transition

compartment

[Compartment:17957] endoplasmic reticulum lumen

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10474536

displayName Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines

eventOf

[Pathway:R-SSC-1650814] Collagen biosynthesis and modifying enzymes - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-SSC-8948234] P4HB:4-Hyp collagen propeptides dissociates - Sus scrofa

inferredFrom

[Reaction:R-HSA-1650808] Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines

output

precedingEvent

[Reaction:R-SSC-2002460] P4HB binds Collagen chains - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-1650808

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-1650814] Collagen biosynthesis and modifying enzymes

(precedingEvent)

[BlackBoxEvent:R-SSC-8948234] P4HB:4-Hyp collagen propeptides dissociates

(inferredTo)

[Reaction:R-HSA-1650808] Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines

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