Reactome Pathway Database

Schema > Reaction > Entries

Initial activation of proMMP13 by plasmin and trypsin Show undefined attributes

catalystActivity

[CatalystActivity:10473484] serine-type endopeptidase activity of Trypsin, plasmin [extracellular region]

category transition

compartment

[Compartment:984] extracellular region

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10473486

displayName Initial activation of proMMP13 by plasmin and trypsin

eventOf

[Pathway:R-SSC-1592389] Activation of Matrix Metalloproteinases - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-1604732] Autocatalytic activation of proMMP13 - Sus scrofa

inferredFrom

[Reaction:R-HSA-1602488] Initial activation of proMMP13 by plasmin and trypsin - Homo sapiens

input

[EntityWithAccessionedSequence:R-SSC-1604702] MMP13(20-471) [extracellular region]

isInDisease false

isInferred true

maxDepth 1

name

Initial activation of proMMP13 by plasmin and trypsin

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-1602488

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-1592389] Activation of Matrix Metalloproteinases

(precedingEvent)

[Reaction:R-SSC-1604732] Autocatalytic activation of proMMP13

(inferredTo)

[Reaction:R-HSA-1602488] Initial activation of proMMP13 by plasmin and trypsin

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