Reactome Pathway Database

Schema > Reaction > Entries

TPMT transfers CH3 from AdoMet to 6MP Show undefined attributes

catalystActivity

[CatalystActivity:10435237] thiopurine S-methyltransferase activity of TPMT [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10435239

displayName TPMT transfers CH3 from AdoMet to 6MP

eventOf

[Pathway:R-SSC-156581] Methylation - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - Sus scrofa

inferredFrom

[Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

TPMT transfers CH3 from AdoMet to 6MP
6-mercaptopurine can be S-methylated

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-158609

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-156581] Methylation

(precedingEvent)

[Reaction:R-SSC-174401] AHCY:NAD+ tetramer hydrolyses AdoHcy

(inferredTo)

[Reaction:R-HSA-158609] TPMT transfers CH3 from AdoMet to 6MP

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