Reactome Pathway Database

Schema > Reaction > Entries

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ Show undefined attributes

catalystActivity

[CatalystActivity:11003094] saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity of AASS tetramer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:11001822] Weiser, Joel, 2025年08月28日

dbId 11003096

displayName saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

eventOf

[Pathway:R-SPO-71064] Lysine catabolism - Schizosaccharomyces pombe

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SPO-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate - Schizosaccharomyces pombe

inferredFrom

[Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+
H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH
AASS tetramer oxidises SACN to 2AMAS

output

precedingEvent

[Reaction:R-SPO-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Schizosaccharomyces pombe

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68324] Schizosaccharomyces pombe

stId R-SPO-70940

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SPO-71064] Lysine catabolism

(inferredTo)

[Reaction:R-HSA-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

(precedingEvent)

[Reaction:R-SPO-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate

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