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TIM23 SORT complex inserts proteins into inner membrane
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authored
[InstanceEdit:1252340] May, B, 2011年04月27日
catalystActivity
[CatalystActivity:1258365] membrane insertase activity of TIM23 SORT:Cargo [mitochondrial inner membrane]
catalystActivityReference
[CatalystActivityReference:9643196] membrane insertase activity of TIM23 SORT:Cargo [mitochondrial inner membrane] Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria
category
transition
compartment
[Compartment:70616] mitochondrial inner membrane
created
[InstanceEdit:1252251] May, B, 2011年04月27日
dbId
1252249
deleted
[Deleted:9697205] Deletion of instance: 1252265
displayName
TIM23 SORT complex inserts proteins into inner membrane
edited
[InstanceEdit:1252340] May, B, 2011年04月27日
input
[Complex:R-SCE-1268011] TIM23 SORT:Cargo [mitochondrial inner membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1252351] Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria
[LiteratureReference:1252350] Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import
[LiteratureReference:1252348] Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria
[LiteratureReference:1252368] Modular structure of the TIM23 preprotein translocase of mitochondria
[LiteratureReference:1252356] Different import pathways through the mitochondrial intermembrane space for inner membrane proteins
[LiteratureReference:1252319] Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway
[LiteratureReference:1252367] Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23
[LiteratureReference:1252376] Tim50, a novel component of the TIM23 preprotein translocase of mitochondria
[LiteratureReference:1252357] The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44
[LiteratureReference:1252293] A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein import
[LiteratureReference:1254306] Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain
[LiteratureReference:1258360] Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism
[LiteratureReference:1258382] Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17
[LiteratureReference:1258397] Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting
[LiteratureReference:1258358] Motor-free mitochondrial presequence translocase drives membrane integration of preproteins
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
TIM23 SORT complex inserts proteins into inner membrane
orthologousEvent
[Reaction:R-HSA-1299482] TIMM23 SORT inserts proteins into inner membrane - Homo sapiens
output
[DefinedSet:R-SCE-1268000] Cargo of TIM23 SORT [mitochondrial inner membrane]
[Complex:R-SCE-1252229] TIM23 Complex [mitochondrial inner membrane]
precedingEvent
[Reaction:R-SCE-1268019] MPP hydrolyzes presequence of inner membrane precursors - Saccharomyces cerevisiae
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1914221] D'Eustachio, P, 2011年11月01日
[InstanceEdit:2108993] Endo, T, 2012年02月12日
schemaClass
Reaction
species
[Species:68322] Saccharomyces cerevisiae
stId
R-SCE-1252249
summation
[Summation:1258370] The TIM23 Complex resides in the inner membrane of the mitoc...
Referrals
(replacementInstances)
[Deleted:9697205] Deletion of instance: 1252265
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