Reactome Pathway Database

Schema > Reaction > Entries

14-3-3 proteins bind AKT-phosphorylated FOXO4 Show undefined attributes

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10187178

displayName 14-3-3 proteins bind AKT-phosphorylated FOXO4

eventOf

[Pathway:R-RNO-9614399] Regulation of localization of FOXO transcription factors - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

14-3-3 proteins bind AKT-phosphorylated FOXO4

output

[Complex:R-RNO-9614653] p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol]

precedingEvent

[BlackBoxEvent:R-RNO-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-9614564

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-9614399] Regulation of localization of FOXO transcription factors

(inferredTo)

[Reaction:R-HSA-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4

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