Reactome Pathway Database

Schema > Reaction > Entries

ACAT2 condenses 2 Ac-CoA to form ACA-CoA Show undefined attributes

catalystActivity

[CatalystActivity:10174179] acetyl-CoA C-acetyltransferase activity of ACAT2 tetramer [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10174181

displayName ACAT2 condenses 2 Ac-CoA to form ACA-CoA

eventOf

[Pathway:R-RNO-191273] Cholesterol biosynthesis - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-RNO-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Rattus norvegicus

inferredFrom

[Reaction:R-HSA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Homo sapiens

input

2 × [SimpleEntity:R-ALL-76183] Ac-CoA [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

ACAT2 condenses 2 Ac-CoA to form ACA-CoA
2 acetyl-CoA => acetoacetyl-CoA + CoA

output

precedingEvent

[Reaction:R-RNO-75848] ACLY tetramer transforms CIT to Ac-CoA - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-8848215

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-191273] Cholesterol biosynthesis

(precedingEvent)

[Reaction:R-RNO-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

(inferredTo)

[Reaction:R-HSA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA

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