Reactome Pathway Database

Schema > Reaction > Entries

AKT1 dephosphorylation by PP2A-B56-beta,gamma Show undefined attributes

catalystActivity

[CatalystActivity:10173458] protein serine/threonine phosphatase activity of PP2A-B56-beta,gamma [cytosol]

category transition

compartment

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10173460

displayName AKT1 dephosphorylation by PP2A-B56-beta,gamma

eventOf

[Pathway:R-RNO-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferredFrom

[Reaction:R-HSA-6811504] AKT1 dephosphorylation by PP2A-B56-beta,gamma - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

AKT1 dephosphorylation by PP2A-B56-beta,gamma

output

regulatedBy

[NegativeRegulation:10056906] Negative regulation by 'PI5P [plasma membrane]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-6811504

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

(inferredTo)

[Reaction:R-HSA-6811504] AKT1 dephosphorylation by PP2A-B56-beta,gamma

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