Reactome Pathway Database

Schema > Reaction > Entries

AKR1B1 reduces Glc to D-sorbitol Show undefined attributes

catalystActivity

[CatalystActivity:10102891] aldose reductase (NADPH) activity of AKR1B1 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10158056

displayName AKR1B1 reduces Glc to D-sorbitol

eventOf

[Pathway:R-RNO-5652227] Fructose biosynthesis - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-RNO-5652195] SORD oxidizes D-sorbitol to Fru - Rattus norvegicus

inferredFrom

[Reaction:R-HSA-5652172] AKR1B1 reduces Glc to D-sorbitol - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

AKR1B1 reduces Glc to D-sorbitol
glucose + NADPH + H+ => sorbitol + NADP+

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-5652172

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-5652227] Fructose biosynthesis

(precedingEvent)

[Reaction:R-RNO-5652195] SORD oxidizes D-sorbitol to Fru

(inferredTo)

[Reaction:R-HSA-5652172] AKR1B1 reduces Glc to D-sorbitol

© 2025 Reactome

Cite Us!