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GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ Show undefined attributes

catalystActivity

[CatalystActivity:10149042] glutathione-disulfide reductase (NADPH) activity of GSR dimer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10149044

displayName GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

eventOf

[Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

output

precedingEvent

[Reaction:R-RNO-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-3323079

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species

(inferredTo)

[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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