Reactome Pathway Database

Schema > Reaction > Entries

CYP27A1 27-hydroxylates CHOL Show undefined attributes

catalystActivity

[CatalystActivity:10101988] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10102048

displayName CYP27A1 27-hydroxylates CHOL

eventOf

[Pathway:R-RNO-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Rattus norvegicus
[Pathway:R-RNO-211976] Endogenous sterols - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-192123] CYP27A1 27-hydroxylates CHOL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP27A1 27-hydroxylates CHOL
cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-192123

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(inferredTo)

[Reaction:R-HSA-192123] CYP27A1 27-hydroxylates CHOL

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