Reactome Pathway Database

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Mevalonate is phosphorylated to mevalonate-5-phosphate Show undefined attributes

catalystActivity

[CatalystActivity:10101724] mevalonate kinase activity of MVK dimer [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10101726

displayName Mevalonate is phosphorylated to mevalonate-5-phosphate

eventOf

[Pathway:R-RNO-191273] Cholesterol biosynthesis - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-RNO-191422] Mevalonate-5-phosphate is further phosphorylated - Rattus norvegicus

inferredFrom

[Reaction:R-HSA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Mevalonate is phosphorylated to mevalonate-5-phosphate
(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)

output

precedingEvent

[Reaction:R-RNO-191352] HMGCR dimer reduces bHMG-CoA to MVA - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-191380

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-191273] Cholesterol biosynthesis

(precedingEvent)

[Reaction:R-RNO-191422] Mevalonate-5-phosphate is further phosphorylated

(inferredTo)

[Reaction:R-HSA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate

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