Reactome Pathway Database

Schema > Reaction > Entries

PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane Show undefined attributes

catalystActivity

[CatalystActivity:10136697] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of PL(C)D4:3xCa2+ [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10136699

displayName PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane

eventOf

[Pathway:R-RNO-1855204] Synthesis of IP3 and IP4 in the cytosol - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-1855214

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-1855204] Synthesis of IP3 and IP4 in the cytosol

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane

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