Reactome Pathway Database

Schema > Reaction > Entries

Recruitment and activation of Chk1 Show undefined attributes

catalystActivity

[CatalystActivity:10100016] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]

category transition

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10100018

displayName Recruitment and activation of Chk1

eventOf

[Pathway:R-RNO-69473] G2/M DNA damage checkpoint - Rattus norvegicus
[Pathway:R-RNO-176187] Activation of ATR in response to replication stress - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

goBiologicalProcess [GO_BiologicalProcess:7962] DNA replication

inferredFrom

[Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Recruitment and activation of Chk1

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-176116

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)