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Arachidonate is hydroxylated to 18-HETE by CYP(1) Show undefined attributes

catalystActivity

[CatalystActivity:10024604] monooxygenase activity of CYP(1) [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10079249

displayName Arachidonate is hydroxylated to 18-HETE by CYP(1)

eventOf

[Pathway:R-MMU-2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1) - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Arachidonate is hydroxylated to 18-HETE by CYP(1)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

output

precedingEvent

[Reaction:R-MMU-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-9915993

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-2142816] Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

(inferredTo)

[Reaction:R-HSA-9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1)

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