Reactome Pathway Database

Schema > BlackBoxEvent > Entries

UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL Show undefined attributes

catalystActivity

[CatalystActivity:9975974] glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]

category omitted

compartment

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10074960

displayName UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL

eventOf

[Pathway:R-MMU-9754706] Atorvastatin ADME - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region - Mus musculus

inferredFrom

[BlackBoxEvent:R-HSA-9756134] UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL

output

precedingEvent

[Reaction:R-MMU-9756169] CYP3A4 monooxygenates ATV to 2-OH-ATV - Mus musculus

releaseDate 2025年09月18日

schemaClass BlackBoxEvent

species

[Species:48892] Mus musculus

stId R-MMU-9756134

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-9754706] Atorvastatin ADME

(precedingEvent)

[Reaction:R-MMU-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region

(inferredTo)

[BlackBoxEvent:R-HSA-9756134] UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL

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