Reactome Pathway Database

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Regulation of localization of FOXO transcription factors Show undefined attributes

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10081920

displayName Regulation of localization of FOXO transcription factors

eventOf

[Pathway:R-MMU-9614085] FOXO-mediated transcription - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-MMU-199299] AKT phosphorylates FOXO transcription factors - Mus musculus
[BlackBoxEvent:R-MMU-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Mus musculus
[Reaction:R-MMU-9614423] 14-3-3 proteins bind AKT-phosphorylated FOXO1 - Mus musculus
[Reaction:R-MMU-9614562] 14-3-3 proteins bind AKT-phosphorylated FOXO3 - Mus musculus
[Reaction:R-MMU-9614564] 14-3-3 proteins bind AKT-phosphorylated FOXO4 - Mus musculus

inferredFrom

[Pathway:R-HSA-9614399] Regulation of localization of FOXO transcription factors - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

Regulation of localization of FOXO transcription factors

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:48892] Mus musculus

stId R-MMU-9614399

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-9614085] FOXO-mediated transcription

(inferredTo)

[Pathway:R-HSA-9614399] Regulation of localization of FOXO transcription factors

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