Reactome Pathway Database

Schema > Reaction > Entries

N-atom dealkylation of caffeine Show undefined attributes

catalystActivity

[CatalystActivity:9971492] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

category transition

compartment

[Compartment:17960] smooth endoplasmic reticulum

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 9971502

displayName N-atom dealkylation of caffeine

eventOf

[Pathway:R-MMU-211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-76426] N-atom dealkylation of caffeine - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

N-atom dealkylation of caffeine

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-76426

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

(inferredTo)

[Reaction:R-HSA-76426] N-atom dealkylation of caffeine

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