Reactome Pathway Database

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Apoptotic execution phase Show undefined attributes

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10081956

displayName Apoptotic execution phase

eventOf

[Pathway:R-MMU-109581] Apoptosis - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:2133501] execution phase of apoptosis

hasDiagram true

hasEHLD false

hasEvent

[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins - Mus musculus
[Pathway:R-MMU-140342] Apoptosis induced DNA fragmentation - Mus musculus
[Reaction:R-MMU-351863] Translocation of active caspase-8 to the mitochondrial membrane - Mus musculus
[Reaction:R-MMU-351948] Mitochondrial recruitment of Drp1 - Mus musculus
[Reaction:R-MMU-351947] Nuclear translocation of catalytic domain of Mst3 - Mus musculus

inferredFrom

[Pathway:R-HSA-75153] Apoptotic execution phase - Homo sapiens

isInDisease false

isInferred true

maxDepth 4

name

Apoptotic execution phase

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:48892] Mus musculus

stId R-MMU-75153

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-109581] Apoptosis

(hasEncapsulatedEvent)

[Pathway:R-MMU-5633008] TP53 Regulates Transcription of Cell Death Genes

(inferredTo)

[Pathway:R-HSA-75153] Apoptotic execution phase

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