Reactome Pathway Database

Schema > Reaction > Entries

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O Show undefined attributes

catalystActivity

[CatalystActivity:9967679] saccharopine dehydrogenase (NADP+, L-lysine-forming) activity of AASS tetramer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 9967681

displayName lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

eventOf

[Pathway:R-MMU-71064] Lysine catabolism - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ - Mus musculus

inferredFrom

[Reaction:R-HSA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O
2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)

output

precedingEvent

[Reaction:R-MMU-508561] alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-70938

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-71064] Lysine catabolism

(precedingEvent)

[Reaction:R-MMU-70940] saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

(inferredTo)

[Reaction:R-HSA-70938] lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

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