Reactome Pathway Database

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EGFR interacts with phospholipase C-gamma Show undefined attributes

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10082078

displayName EGFR interacts with phospholipase C-gamma

eventOf

[Pathway:R-MMU-177929] Signaling by EGFR - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:141] signal transduction

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-MMU-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Mus musculus
[Reaction:R-MMU-212710] EGFR activates PLC-gamma1 by phosphorylation - Mus musculus
[Reaction:R-MMU-212713] Active PLC-gamma1 dissociates from EGFR - Mus musculus

inferredFrom

[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

EGFR interacts with phospholipase C-gamma

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:48892] Mus musculus

stId R-MMU-212718

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-177929] Signaling by EGFR

(inferredTo)

[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma

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