Reactome Pathway Database

Schema > Reaction > Entries

5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al Show undefined attributes

catalystActivity

[CatalystActivity:9981944] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 9982491

displayName 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al

eventOf

[Pathway:R-MMU-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-193713] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) - Mus musculus

inferredFrom

[Reaction:R-HSA-193780] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADP+ + H2O

output

precedingEvent

[Reaction:R-MMU-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-193780

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol

(precedingEvent)

[Reaction:R-MMU-193713] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)

(inferredTo)

[Reaction:R-HSA-193780] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al

© 2025 Reactome

Cite Us!