Reactome Pathway Database

Schema > Reaction > Entries

ODC dimerizes Show undefined attributes

authored

[InstanceEdit:9955550] D'Eustachio, Peter, 2025年06月10日

catalystActivity

[CatalystActivity:9955553] ornithine decarboxylase activator activity of PXLP-K69-ODC1 [cytosol]

catalystActivityReference [CatalystActivityReference:9955565] ornithine decarboxylase activator activity of PXLP-K69-ODC1 [cytosol] Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9955584] D'Eustachio, Peter, 2025年06月10日

dbId 9955574

displayName ODC dimerizes

edited

[InstanceEdit:9955550] D'Eustachio, Peter, 2025年06月10日

eventOf

[Pathway:R-HSA-351202] Metabolism of polyamines - Homo sapiens

followingEvent

[Reaction:R-HSA-70692] ornithine => putrescine + CO2 - Homo sapiens

input

2 × [EntityWithAccessionedSequence:R-HSA-70689] PXLP-K69-ODC1 [cytosol]

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:9955578] Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding

maxDepth 1

modified [InstanceEdit:11064438] Weiser, Joel, 2025年08月28日

name

ODC dimerizes

orthologousEvent

output

[Complex:R-HSA-9955582] PXLP-K69-ODC1 dimer [cytosol]

previousReviewStatus [ReviewStatus:9821383] three stars

regulatedBy

[NegativeRegulation:9955811] Negative regulation by 'ODC:OAZ complex [cytosol]'

regulationReference

[RegulationReference:9955814] Negative regulation by 'ODC:OAZ complex [cytosol]' Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1

releaseDate 2025年09月18日

releaseStatus NEW

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9962972] Hill, David P, 2025年08月12日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9955574

summation

[Summation:9955564] Cytosolic pyridoxal phosphate-conjugated ornithine decarboxy...

Referrals

(hasEvent)

[Pathway:R-HSA-351202] Metabolism of polyamines

(precedingEvent)

[Reaction:R-HSA-70692] ornithine => putrescine + CO2

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