Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
SRD5A3 reduces polyprenal to dolichal
Show undefined attributes
Go to Details
authored
[InstanceEdit:9937271] D'Eustachio, Peter, 2025年01月29日
catalystActivity
[CatalystActivity:9937303] polyprenal reductase activity of SRD5A3 [endoplasmic reticulum membrane]
catalystActivityReference
[CatalystActivityReference:9937313] polyprenal reductase activity of SRD5A3 [endoplasmic reticulum membrane] A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
category
transition
compartment
[Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:9937296] D'Eustachio, Peter, 2025年01月30日
crossReference
[DatabaseIdentifier:9937285] RHEA:80729
dbId
9937295
deleted
[Deleted:9937351] Deletion of instance: 4419979
displayName
SRD5A3 reduces polyprenal to dolichal
edited
[InstanceEdit:9938253] D'Eustachio, Peter, 2025年02月11日
eventOf
[Pathway:R-HSA-446199] Synthesis of dolichyl-phosphate - Homo sapiens
followingEvent
[Reaction:R-HSA-9937340] DHRSX reduces dolichal to dolichol - Homo sapiens
input
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-9937308] pNAL [cytoplasmic side of endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:4420007] SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
[LiteratureReference:4420042] Next generation sequencing in a family with autosomal recessive Kahrizi syndrome (OMIM 612713) reveals a homozygous frameshift mutation in SRD5A3
[LiteratureReference:4420017] SRD5A3-CDG: a patient with a novel mutation
[LiteratureReference:9937278] A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
SRD5A3 reduces polyprenal to dolichal
a di-trans,poly-cis-polyprenal + NADPH + H(+) => a di-trans,poly-cis-dolichal + NADP(+)
orthologousEvent
[Reaction:R-PFA-9937295] SRD5A3 reduces polyprenal to dolichal - Plasmodium falciparum
[Reaction:R-SCE-9937295] SRD5A3 reduces polyprenal to dolichal - Saccharomyces cerevisiae
[Reaction:R-SPO-9937295] SRD5A3 reduces polyprenal to dolichal - Schizosaccharomyces pombe
[Reaction:R-DDI-9937295] SRD5A3 reduces polyprenal to dolichal - Dictyostelium discoideum
[Reaction:R-CEL-9937295] SRD5A3 reduces polyprenal to dolichal - Caenorhabditis elegans
[Reaction:R-DME-9937295] SRD5A3 reduces polyprenal to dolichal - Drosophila melanogaster
[Reaction:R-GGA-9937295] SRD5A3 reduces polyprenal to dolichal - Gallus gallus
[Reaction:R-XTR-9937295] SRD5A3 reduces polyprenal to dolichal - Xenopus tropicalis
[Reaction:R-DRE-9937295] SRD5A3 reduces polyprenal to dolichal - Danio rerio
[Reaction:R-SSC-9937295] SRD5A3 reduces polyprenal to dolichal - Sus scrofa
[Reaction:R-BTA-9937295] SRD5A3 reduces polyprenal to dolichal - Bos taurus
[Reaction:R-CFA-9937295] SRD5A3 reduces polyprenal to dolichal - Canis familiaris
[Reaction:R-RNO-9937295] SRD5A3 reduces polyprenal to dolichal - Rattus norvegicus
[Reaction:R-MMU-9937295] SRD5A3 reduces polyprenal to dolichal - Mus musculus
output
[SimpleEntity:R-ALL-9937289] DCHAL [cytoplasmic side of endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[Reaction:R-HSA-9937298] DHRSX oxidizes polyprenol to polyprenal - Homo sapiens
releaseDate
2025年03月26日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9939401] Hill, David P, 2025年02月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9937295
summation
[Summation:9937290] SRD5A3 (Polyprenal reductase) associated with the cytoplasmi...
Referrals
(replacementInstances)
[Deleted:9937351] Deletion of instance: 4419979
(normalReaction)
[FailedReaction:R-HSA-4755572] Defective SRD5A3 does not reduce pPNOL to DCHOL
(hasEvent)
[Pathway:R-HSA-446199] Synthesis of dolichyl-phosphate
(precedingEvent)
[Reaction:R-HSA-9937340] DHRSX reduces dolichal to dolichol
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル