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Arachidonate is epoxidated to 14,15-EET by CYP(5) Show undefined attributes

authored

[InstanceEdit:2142839] Williams, MG, 2012年02月24日

catalystActivity

[CatalystActivity:2161882] monooxygenase activity of CYP(5) [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:9915999] D'Eustachio, Peter, 2024年07月19日

crossReference

[DatabaseIdentifier:9916002] RHEA:51473

dbId 9915997

displayName Arachidonate is epoxidated to 14,15-EET by CYP(5)

edited

[InstanceEdit:2142839] Williams, MG, 2012年02月24日

eventOf

[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - Homo sapiens

followingEvent

[Reaction:R-HSA-9915994] 14,15-EET is hydrolysed to 14,15-DHET by EPHX2 - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

name

Arachidonate is epoxidated to 14,15-EET by CYP(5)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-428990] SLC27A1 transports arachidonate across the ER membrane - Homo sapiens

releaseDate 2024年09月11日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9917333] Hill, David P, 2024年08月02日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9915997

summation

[Summation:9915970] Several cytochrome P450s (CYPs) convert arachidonate to 14,1...

Referrals

(precedingEvent)

[Reaction:R-HSA-9915994] 14,15-EET is hydrolysed to 14,15-DHET by EPHX2

(hasEvent)

[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

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