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CD274 Transcription
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authored
[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025年08月26日
[InstanceEdit:9927358] Tiwari, Krishna, 2024年11月05日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9909599] Tiwari, Krishna, 2024年05月14日
dbId
9909623
displayName
CD274 Transcription
edited
[InstanceEdit:9962761] Gillespie, Marc E, 2025年08月08日
eventOf
[Pathway:R-HSA-9909649] Regulation of PD-L1(CD274) transcription - Homo sapiens
followingEvent
[Reaction:R-HSA-9924968] CD274 mRNA binds miR-429 RISC - Homo sapiens
[Reaction:R-HSA-9925320] CD274 mRNA binds miR-142-5p RISC - Homo sapiens
[Reaction:R-HSA-9925289] CD274 mRNA binds miR-424 RISC - Homo sapiens
[Reaction:R-HSA-9924908] CD274 mRNA binds miR-93 RISC - Homo sapiens
[Reaction:R-HSA-9925324] CD274 mRNA binds miR-200B/C RISC - Homo sapiens
[BlackBoxEvent:R-HSA-9925190] CD274 translation - Homo sapiens
[Reaction:R-HSA-9925158] CD274 mRNA binds miR-152 RISC - Homo sapiens
[Reaction:R-HSA-9925159] CD274 mRNA binds miR-140 RISC - Homo sapiens
[Reaction:R-HSA-9925095] CD274 mRNA binds miR-340 RISC - Homo sapiens
[Reaction:R-HSA-9924921] CD274 mRNA binds miR-34 RISC - Homo sapiens
[Reaction:R-HSA-9925246] CD274 mRNA binds miR-Let7-a1 RISC - Homo sapiens
[Reaction:R-HSA-9925087] CD274 mRNA binds miR-138-5p RISC - Homo sapiens
[Reaction:R-HSA-9925270] CD274 mRNA binds miR-148a-3p RISC - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9701419] CD274 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9912228] PD-L1: expression regulation
[LiteratureReference:9912234] Mechanisms Controlling PD-L1 Expression in Cancer
[LiteratureReference:9912160] Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics
[LiteratureReference:9912147] PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs
[LiteratureReference:9912250] Regulation of PD-L1 expression in cancer and clinical implications in immunotherapy
maxDepth
1
modified
[InstanceEdit:9965199] Matthews, Lisa, 2025年08月26日
name
CD274 Transcription
output
[EntityWithAccessionedSequence:R-HSA-9909617] CD274 mRNA [cytosol]
precedingEvent
[Reaction:R-HSA-9909610] AP-1 binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909594] ATF3 binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909635] BRD4 binding to CD274 gene chromatin - Homo sapiens
[Reaction:R-HSA-9909632] CTNNB1 binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909618] HIF1A,EPAS1 binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909608] IRF1 binding to CD274 promoter - Homo sapiens
[Reaction:R-HSA-9909602] MYC,MYCN binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909622] NFKB_complex binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909652] NFE2L2 binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909657] STAT1 dimer binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909609] STAT3 dimer binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909654] YAP1/TAZ binding to CD274 gene - Homo sapiens
[Reaction:R-HSA-9909628] Trimethylation of CD274 gene chromatin by MLL1/3 complex - Homo sapiens
[Reaction:R-HSA-9909631] Trimethylation of CD274 gene promoter by EZH2 - Homo sapiens
previousReviewStatus
[ReviewStatus:9821383] three stars
regulatedBy
[PositiveGeneExpressionRegulation:9909616] Positive gene expression regulation by 'STAT3_dimer:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909629] Positive gene expression regulation by 'STAT1_dimer:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909638] Positive gene expression regulation by 'IRF1:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909612] Positive gene expression regulation by 'NFKB_Complex:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909656] Positive gene expression regulation by 'MYC,MYCN:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909639] Positive gene expression regulation by 'HIF1A,EPAS1:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909658] Positive gene expression regulation by 'NRF2:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909634] Positive gene expression regulation by 'ATF3:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909621] Positive gene expression regulation by 'CTNNB1:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909644] Positive gene expression regulation by 'AP-1:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909624] Positive gene expression regulation by 'YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909643] Positive gene expression regulation by 'BRD4:CD274 gene chromatin [nucleoplasm]'
[PositiveGeneExpressionRegulation:9909640] Positive gene expression regulation by 'MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm]'
[NegativeGeneExpressionRegulation:9909650] Negative gene expression regulation by 'PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm]'
regulationReference
[RegulationReference:9912801] Positive gene expression regulation by 'STAT3_dimer:CD274 gene [nucleoplasm]' Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
[RegulationReference:9912824] Positive gene expression regulation by 'STAT1_dimer:CD274 gene [nucleoplasm]' IFN?-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling
[RegulationReference:9912821] Positive gene expression regulation by 'IRF1:CD274 gene [nucleoplasm]' IFN?-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling
[RegulationReference:9912809] Positive gene expression regulation by 'NFKB_Complex:CD274 gene [nucleoplasm]' NF-?B plays a key role in inducing CD274 expression in human monocytes after lipopolysaccharide treatment
[RegulationReference:9912802] Positive gene expression regulation by 'MYC,MYCN:CD274 gene [nucleoplasm]' C-Myc regulates PD-L1 expression in esophageal squamous cell carcinoma
[RegulationReference:9912828] Positive gene expression regulation by 'HIF1A,EPAS1:CD274 gene [nucleoplasm]' The relationship between expression of PD-L1 and HIF-1? in glioma cells under hypoxia
[RegulationReference:9912806] Positive gene expression regulation by 'NRF2:CD274 gene [nucleoplasm]' Tumor-immune microenvironment and NRF2 associate with clinical efficacy of PD-1 blockade combined with chemotherapy in lung squamous cell carcinoma
[RegulationReference:9912803] Positive gene expression regulation by 'ATF3:CD274 gene [nucleoplasm]' ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
[RegulationReference:9912798] Positive gene expression regulation by 'CTNNB1:CD274 gene [nucleoplasm]' ?-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion
[RegulationReference:9912812] Positive gene expression regulation by 'AP-1:CD274 gene [nucleoplasm]' Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy
[RegulationReference:9912805] Positive gene expression regulation by 'YAP1:WWNT1:TEADs:CD274 gene [nucleoplasm]' The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
[RegulationReference:9912816] Positive gene expression regulation by 'BRD4:CD274 gene [nucleoplasm]' BRD4 inhibition suppresses PD-L1 expression in triple-negative breast cancer
[RegulationReference:9912815] Positive gene expression regulation by 'MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm]' The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion
[RegulationReference:9912829] Negative gene expression regulation by 'PRC2(EZH2) Core:H3K27me3 Nucleosome:CD274 gene [nucleoplasm]' EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma
releaseDate
2025年09月18日
releaseStatus
NEW
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025年08月26日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9909623
summation
[Summation:9912811] The transcriptional regulation of CD274 (PD-L1/programmed de...
Referrals
(precedingEvent)
[Reaction:R-HSA-9924968] CD274 mRNA binds miR-429 RISC
[Reaction:R-HSA-9925320] CD274 mRNA binds miR-142-5p RISC
[Reaction:R-HSA-9925289] CD274 mRNA binds miR-424 RISC
[Reaction:R-HSA-9924908] CD274 mRNA binds miR-93 RISC
[Reaction:R-HSA-9925324] CD274 mRNA binds miR-200B/C RISC
[BlackBoxEvent:R-HSA-9925190] CD274 translation
[Reaction:R-HSA-9925158] CD274 mRNA binds miR-152 RISC
[Reaction:R-HSA-9925159] CD274 mRNA binds miR-140 RISC
[Reaction:R-HSA-9925095] CD274 mRNA binds miR-340 RISC
[Reaction:R-HSA-9924921] CD274 mRNA binds miR-34 RISC
[Reaction:R-HSA-9925246] CD274 mRNA binds miR-Let7-a1 RISC
[Reaction:R-HSA-9925087] CD274 mRNA binds miR-138-5p RISC
[Reaction:R-HSA-9925270] CD274 mRNA binds miR-148a-3p RISC
(hasEvent)
[Pathway:R-HSA-9909649] Regulation of PD-L1(CD274) transcription
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