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Schema
>
BlackBoxEvent
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Entries
TGFBR3 transcription
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authored
[InstanceEdit:9840908] Tiwari, Krishna, 2023年07月25日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9839369] Tiwari, Krishna, 2023年07月05日
dbId
9839371
displayName
TGFBR3 transcription
edited
[InstanceEdit:9840908] Tiwari, Krishna, 2023年07月25日
eventOf
[Pathway:R-HSA-9839394] TGFBR3 expression - Homo sapiens
followingEvent
[Reaction:R-HSA-9860168] MIR23B microRNA binds 3'UTR of TGFBR3 mRNA - Homo sapiens
[Reaction:R-HSA-9860139] MIR27B microRNA binds 3'UTR of TGFBR3 mRNA - Homo sapiens
[Reaction:R-HSA-9860160] MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA - Homo sapiens
[BlackBoxEvent:R-HSA-9839396] TGFBR3 translation - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9839359] TGFBR3 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9840068] Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta
[LiteratureReference:9840170] Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis
[LiteratureReference:9840062] Type III TGF-? receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma
[LiteratureReference:9840087] Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta
[LiteratureReference:9840047] HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3
[LiteratureReference:9840181] KLF16 Downregulates the Expression of Tumor Suppressor Gene TGFBR3 to Promote Bladder Cancer Proliferation and Migration
maxDepth
1
modified
[InstanceEdit:9910927] Matthews, Lisa, 2024年05月24日
name
TGFBR3 transcription
output
[EntityWithAccessionedSequence:R-HSA-9839365] TGFBR3 mRNA [nucleoplasm]
precedingEvent
[Reaction:R-HSA-9860125] Binding of ATRA to TGFBR3 gene promoter - Homo sapiens
[Reaction:R-HSA-9860169] Binding of MyoD to TGFBR3 gene promoter - Homo sapiens
[Reaction:R-HSA-9860130] Binding of SP1 to TGFBR3 gene promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:9839360] Positive gene expression regulation by 'MyoD:TGFBR3 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9839385] Positive gene expression regulation by 'SP1:TGFBR3 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9839398] Positive gene expression regulation by 'aTRA:TGFBR3 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9839361] Negative gene expression regulation by '(2xp-2S-SMAD3):SMAD4:SP1:EP300 [nucleoplasm]'
[NegativeGeneExpressionRegulation:9839393] Negative gene expression regulation by 'MYCN [nucleoplasm]'
[NegativeGeneExpressionRegulation:9839386] Negative gene expression regulation by 'HELLS [nucleoplasm]'
[NegativeGeneExpressionRegulation:9839387] Negative gene expression regulation by 'KLF16 [nucleoplasm]'
regulationReference
[RegulationReference:9840096] Positive gene expression regulation by 'MyoD:TGFBR3 gene [nucleoplasm]' Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta
[RegulationReference:9840095] Positive gene expression regulation by 'SP1:TGFBR3 gene [nucleoplasm]' Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta
[RegulationReference:9840149] Positive gene expression regulation by 'aTRA:TGFBR3 gene [nucleoplasm]' Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation. Cloning of murine betaglycan gene promoter and its modulation by MyoD, retinoic acid, and transforming growth factor-beta
[RegulationReference:9840051] Negative gene expression regulation by '(2xp-2S-SMAD3):SMAD4:SP1:EP300 [nucleoplasm]' Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta
[RegulationReference:9840179] Negative gene expression regulation by 'MYCN [nucleoplasm]' Type III TGF-? receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma
[RegulationReference:9840039] Negative gene expression regulation by 'HELLS' HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3
[RegulationReference:9840048] Negative gene expression regulation by 'KLF16' KLF16 Downregulates the Expression of Tumor Suppressor Gene TGFBR3 to Promote Bladder Cancer Proliferation and Migration
releaseDate
2024年06月15日
reviewStatus
[ReviewStatus:9821383] three stars
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9839371
summation
[Summation:9840151] TGFBR3 is transcriptionally regulated by SP1, MyoD and its p...
Referrals
(precedingEvent)
[Reaction:R-HSA-9860168] MIR23B microRNA binds 3'UTR of TGFBR3 mRNA
[Reaction:R-HSA-9860139] MIR27B microRNA binds 3'UTR of TGFBR3 mRNA
[Reaction:R-HSA-9860160] MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA
[BlackBoxEvent:R-HSA-9839396] TGFBR3 translation
(hasEvent)
[Pathway:R-HSA-9839394] TGFBR3 expression
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