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Schema
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Reaction
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Entries
p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene
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authored
[InstanceEdit:9756705] May, Bruce, 2021年10月16日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9756721] May, Bruce, 2021年10月18日
dbId
9756724
displayName
p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene
edited
[InstanceEdit:9756705] May, Bruce, 2021年10月16日
eventOf
[Pathway:R-HSA-9754189] Germ layer formation at gastrulation - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9758501] Expression of MIXL1 in the primitive streak - Homo sapiens
inferredFrom
[Reaction:R-MMU-9756720] p-2S-Smad2,3:Trim33 and p-2S-Smad2,3LSmad4 bind Foxh1:Mixl1 gene - Mus musculus
input
[EntityWithAccessionedSequence:R-HSA-3451168] CTNNB1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-452232] EOMES [nucleoplasm]
[Complex:R-HSA-9756732] FOXH1:MIXL1 gene [nucleoplasm]
[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
[Complex:R-HSA-9760362] p-2S-SMAD2,3:TRIM33 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9754296] TBPL2 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:9757060] ?-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4
[LiteratureReference:9754295] TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes
[LiteratureReference:9773619] SMADs and YAP compete to control elongation of ?-catenin:LEF-1-recruited RNAPII during hESC differentiation
[LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene
output
[Complex:R-HSA-9756735] p-2S-SMAD2,3:TRIM33:p-2S-SMAD2,3:SMAD4:CTNNB1:FOXH1:EOMES:TBPL2:MIXL1 gene [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
releaseDate
2022年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9773645] Tam, Patrick P L, 2022年05月08日
[InstanceEdit:9794593] Probst, Simone, 2022年07月18日
[InstanceEdit:9796183] Zissel, Lea, 2022年07月18日
[InstanceEdit:9796182] Salehin, Nazmus, 2022年05月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9756724
summation
[Summation:9760364] In differentiating human embryonic stem cells (ESCs), beta-c...
updateTrackers
[UpdateTracker:9847034] Update Tracker - [Reaction:9756724] p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene - v82:[addInput, addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9847034] Update Tracker - [Reaction:9756724] p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene - v82:[addInput, addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-9754189] Germ layer formation at gastrulation
(precedingEvent)
[BlackBoxEvent:R-HSA-9758501] Expression of MIXL1 in the primitive streak
(inferredTo)
[Reaction:R-MMU-9756720] p-2S-Smad2,3:Trim33 and p-2S-Smad2,3LSmad4 bind Foxh1:Mixl1 gene
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