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Schema
>
BlackBoxEvent
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Entries
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL
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authored
[InstanceEdit:9756176] Jassal, Bijay, 2021年10月12日
catalystActivity
[CatalystActivity:9756328] glucuronosyltransferase activity of UGT1A3 [endoplasmic reticulum membrane]
category
uncertain
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9756176] Jassal, Bijay, 2021年10月12日
dbId
9756183
displayName
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL
edited
[InstanceEdit:9756176] Jassal, Bijay, 2021年10月12日
eventOf
[Pathway:R-HSA-9754706] Atorvastatin ADME - Homo sapiens
followingEvent
[Reaction:R-HSA-9756150] PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV - Homo sapiens
[Reaction:R-HSA-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region - Homo sapiens
input
[ChemicalDrug:R-ALL-9756325] 4-OH-ATV [cytosol]
[SimpleEntity:R-ALL-158601] UDP-GlcA [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9756153] UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo
[LiteratureReference:9756170] Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization
[LiteratureReference:9756892] Statin Lactonization by Uridine 5'-Diphospho-glucuronosyltransferases (UGTs)
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL
orthologousEvent
[BlackBoxEvent:R-DDI-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Dictyostelium discoideum
[BlackBoxEvent:R-GGA-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Gallus gallus
[BlackBoxEvent:R-SSC-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Sus scrofa
[BlackBoxEvent:R-BTA-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Bos taurus
[BlackBoxEvent:R-RNO-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Rattus norvegicus
[BlackBoxEvent:R-MMU-9756183] UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL - Mus musculus
output
[SimpleEntity:R-ALL-9756326] 4-OH-ATVL [cytosol]
[SimpleEntity:R-ALL-2162232] GlcA [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-110096] UDP [cytosol]
precedingEvent
[Reaction:R-HSA-9756162] CYP3A4 monooxygenates ATV to 4-OH-ATV - Homo sapiens
releaseDate
2022年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9767610] Huddart, Rachel, 2022年03月01日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9756183
summation
[Summation:9756891] The acid form of 4-hydroxyatorvastatin (4-OH-ATV) can be con...
Referrals
(precedingEvent)
[Reaction:R-HSA-9757139] ABCB1,ABCC2 transport ATVs from cytosol to extracellular region
[Reaction:R-HSA-9756150] PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV
(hasEvent)
[Pathway:R-HSA-9754706] Atorvastatin ADME
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