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Schema
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BlackBoxEvent
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Entries
26S proteasome degrades HIFalpha
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authored
[InstanceEdit:9761879] Rothfels, Karen, 2022年01月16日
catalystActivity
[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9755309] Rothfels, Karen, 2021年10月07日
dbId
9755303
displayName
26S proteasome degrades HIFalpha
edited
[InstanceEdit:9761879] Rothfels, Karen, 2022年01月16日
eventOf
[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input
[Complex:R-HSA-8956079] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1234014] Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm
[LiteratureReference:1233955] Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
[LiteratureReference:392092] Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
[LiteratureReference:1233947] HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
26S proteasome degrades HIFalpha
negativePrecedingEvent
[NegativePrecedingEvent:9767199] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent
[BlackBoxEvent:R-CEL-9755303] 26S proteasome degrades HIFalpha - Caenorhabditis elegans
[BlackBoxEvent:R-DME-9755303] 26S proteasome degrades HIFalpha - Drosophila melanogaster
[BlackBoxEvent:R-GGA-9755303] 26S proteasome degrades HIFalpha - Gallus gallus
[BlackBoxEvent:R-XTR-9755303] 26S proteasome degrades HIFalpha - Xenopus tropicalis
[BlackBoxEvent:R-DRE-9755303] 26S proteasome degrades HIFalpha - Danio rerio
[BlackBoxEvent:R-SSC-9755303] 26S proteasome degrades HIFalpha - Sus scrofa
[BlackBoxEvent:R-BTA-9755303] 26S proteasome degrades HIFalpha - Bos taurus
[BlackBoxEvent:R-CFA-9755303] 26S proteasome degrades HIFalpha - Canis familiaris
[BlackBoxEvent:R-RNO-9755303] 26S proteasome degrades HIFalpha - Rattus norvegicus
[BlackBoxEvent:R-MMU-9755303] 26S proteasome degrades HIFalpha - Mus musculus
output
[Complex:R-HSA-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
[DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent
[Reaction:R-HSA-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha - Homo sapiens
releaseDate
2022年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9768153] Somers, Julia, 2022年03月04日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9755303
summation
[Summation:1235016] Destruction of ubiquitinated HIF-alpha can occur in both the...
Referrals
(hasEvent)
[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)
[NegativePrecedingEvent:9767172] Futile Cycle: 26S proteasome degrades HIFalpha
[NegativePrecedingEvent:9767170] Futile Cycle: 26S proteasome degrades HIFalpha
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