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Schema
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Reaction
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Entries
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
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authored
[InstanceEdit:847735] Shamovsky, V, 2010年06月01日
catalystActivity
[CatalystActivity:975181] protein kinase activity of TRAF6:hp-IRAK1:Pellino [endosome membrane]
category
transition
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:975168] Shamovsky, V, 2010年09月22日
dbId
975139
displayName
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
edited
[InstanceEdit:1014262] Shamovsky, V, 2010年11月15日
eventOf
[Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Homo sapiens
followingEvent
[Reaction:R-HSA-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
- Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-975143] TRAF6:hp-IRAK1:Pellino [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:450692] The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
[LiteratureReference:450812] Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4
[LiteratureReference:450816] Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
orthologousEvent
[Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Drosophila melanogaster
[Reaction:R-SSC-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Sus scrofa
[Reaction:R-BTA-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Bos taurus
[Reaction:R-CFA-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Canis familiaris
[Reaction:R-RNO-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Rattus norvegicus
[Reaction:R-MMU-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]
precedingEvent
[Reaction:R-HSA-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation - Homo sapiens
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:983288] Gillespie, ME, 2010年10月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-975139
summation
[Summation:940396] Both IRAK1 and IRAK4 were shown to phosphorylate Pellino iso...
updateTrackers
[UpdateTracker:9788476] Update Tracker - [Reaction:975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - v42:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788476] Update Tracker - [Reaction:975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - v42:[modifyText]
(hasEvent)
[Pathway:R-HSA-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
(precedingEvent)
[Reaction:R-HSA-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
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