Reactome Pathway Database

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p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter Show undefined attributes

authored

[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:9736994] Orlic-Milacic, Marija, 2021年07月15日

dbId 9736992

displayName p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter

edited

eventOf

[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-2187293] SMAD2/3:SMAD4 complex positively regulates JUNB transcription - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:2187286] Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter

negativePrecedingEvent

[NegativePrecedingEvent:9754432] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2

output

[Complex:R-HSA-9736993] p-2S-SMAD2,3:SMAD4:JUNB gene [nucleoplasm]

precedingEvent

[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9736992

summation

[Summation:9736991] SMAD2/3:SMAD4 heterotrimer binds SMAD binding site in the pr...

Referrals

(precedingEvent)

[BlackBoxEvent:R-HSA-2187293] SMAD2/3:SMAD4 complex positively regulates JUNB transcription

(hasEvent)

[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

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