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Schema
>
Reaction
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Entries
EDNRA, EDNRB bind non-selective ERAs
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authored
[InstanceEdit:9731395] Jassal, Bijay, 2021年05月20日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:9731395] Jassal, Bijay, 2021年05月20日
dbId
9731393
definition
Antagonist
displayName
EDNRA, EDNRB bind non-selective ERAs
edited
[InstanceEdit:9731395] Jassal, Bijay, 2021年05月20日
[InstanceEdit:9773839] Matthews, Lisa, 2022年05月10日
eventOf
[Pathway:R-HSA-375276] Peptide ligand-binding receptors - Homo sapiens
input
[DefinedSet:R-HSA-388547] EDNRA,EDNRB [plasma membrane]
[DefinedSet:R-ALL-9731346] non-selective ERAs [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9731877] Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
[LiteratureReference:9731907] Pharmacokinetic-pharmacodynamic relationships of macitentan, a new endothelin receptor antagonist, after multiple dosing in healthy Korean subjects
[LiteratureReference:9731881] Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
EDNRA, EDNRB bind non-selective ERAs
EDNRA, EDNRB bind EDNR antagonists
orthologousEvent
[Reaction:R-GGA-9731393] EDNRA, EDNRB bind non-selective ERAs - Gallus gallus
[Reaction:R-XTR-9731393] EDNRA, EDNRB bind non-selective ERAs - Xenopus tropicalis
[Reaction:R-DRE-9731393] EDNRA, EDNRB bind non-selective ERAs - Danio rerio
[Reaction:R-SSC-9731393] EDNRA, EDNRB bind non-selective ERAs - Sus scrofa
[Reaction:R-BTA-9731393] EDNRA, EDNRB bind non-selective ERAs - Bos taurus
[Reaction:R-CFA-9731393] EDNRA, EDNRB bind non-selective ERAs - Canis familiaris
[Reaction:R-RNO-9731393] EDNRA, EDNRB bind non-selective ERAs - Rattus norvegicus
[Reaction:R-MMU-9731393] EDNRA, EDNRB bind non-selective ERAs - Mus musculus
output
[Complex:R-HSA-9731404] EDNRA,EDNRB:non-selective ERAs [plasma membrane]
reactionType
[DrugActionType:9725064] Antagonist
releaseDate
2022年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9767610] Huddart, Rachel, 2022年03月01日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9731393
summation
[Summation:9731914] Endothelins (EDNs) are 21-amino acid vasoconstricting peptid...
Referrals
(hasEvent)
[Pathway:R-HSA-375276] Peptide ligand-binding receptors
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