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Search ...
Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
p-7Y ALK V1180L [plasma membrane]
Show undefined attributes
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compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-9715316] p-7Y ALK V1180L dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9715316] p-7Y ALK V1180L dimer [plasma membrane] - Homo sapiens
created
[InstanceEdit:9715288] Rothfels, Karen, 2021年02月17日
crossReference
[DatabaseIdentifier:11945163] Mondo:0005097
[DatabaseIdentifier:9715226] COSMIC:COSV66587894
dbId
9715289
disease
[Disease:1981182] lung squamous cell carcinoma
displayName
p-7Y ALK V1180L [plasma membrane]
endCoordinate
1620
hasModifiedResidue
[ReplacedResidue:9715220] L-valine 1180 replaced with L-leucine
[ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096
[ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278
[ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282
[ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283
[ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359
[ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507
[ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
inDisease
true
literatureReference
[LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
maxDepth
1
name
p-7Y ALK V1180L
ALK tyrosine kinase receptor
ALK_HUMAN
referenceEntity
[ReferenceGeneProduct:uniprot:Q9UM73] UniProt:Q9UM73 ALK
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-9715289
startCoordinate
19
Referrals
(hasComponent)
[Complex:R-HSA-9715316] p-7Y ALK V1180L dimer [plasma membrane]
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