Reactome Pathway Database

Schema > Reaction > Entries

ALK fusions phosphorylate PLCG1 Show undefined attributes

authored

[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日

catalystActivity

[CatalystActivity:9711942] protein tyrosine kinase activity of PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane]

category transition

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9712080] Rothfels, Karen, 2021年01月14日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9712086

disease

[Disease:1500689] cancer

displayName ALK fusions phosphorylate PLCG1

edited

[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日

eventOf

[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

ALK fusions phosphorylate PLCG1

normalReaction [Reaction:R-HSA-9700171] Active ALK phosphorylates PLCG1

output

precedingEvent

[Reaction:R-HSA-9710917] ALK fusion proteins bind PLCG1 - Homo sapiens

releaseDate 2021年06月09日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9712086

summation

[Summation:9724121] PLC gamma is phosphorylated downstream of ALK fusions, activ...

Referrals

(precedingEvent)

[BlackBoxEvent:R-HSA-9851137] STAT3-dependent DNMT1 gene expression

(hasEvent)

[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants

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