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Entries
Cytoprotection by HMOX1
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authored
[InstanceEdit:9707640] Stephan, Ralf, 2020年11月12日
created
[InstanceEdit:9707568] Stephan, Ralf, 2020年11月19日
dbId
9707564
displayName
Cytoprotection by HMOX1
edited
[InstanceEdit:9707640] Stephan, Ralf, 2020年11月12日
eventOf
[Pathway:R-HSA-9711123] Cellular response to chemical stress - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:376615] cellular response to oxidative stress
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-9707587] Regulation of HMOX1 expression and activity - Homo sapiens
[Reaction:R-HSA-1250272] TXNIP binds NLRP3 - Homo sapiens
[Reaction:R-HSA-9709918] PTK6 phosphorylates STAT3 - Homo sapiens
[Reaction:R-HSA-189398] HMOX1 dimer, HMOX2 cleave heme - Homo sapiens
[Reaction:R-HSA-189384] BLVRA:Zn2+, BLVRB reduce BV to BIL - Homo sapiens
[BlackBoxEvent:R-HSA-9709366] CO translocates from cytosol to mitochondrial inner membrane - Homo sapiens
[Reaction:R-HSA-9709406] CO binds to Cytochrome c oxidase - Homo sapiens
[Reaction:R-HSA-163214] Electron transfer from reduced cytochrome c to molecular oxygen - Homo sapiens
[BlackBoxEvent:R-HSA-9709396] CO translocates from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-9709317] CO binds to free ferrohemoglobin - Homo sapiens
[Reaction:R-HSA-9707504] H2O2 oxidises ferrohemoglobin to MetHb - Homo sapiens
[Reaction:R-HSA-9709360] H2O2 reduces MetHb - Homo sapiens
[BlackBoxEvent:R-HSA-9709879] BIL scavenges O2.- - Homo sapiens
[Reaction:R-HSA-9661405] ABCC1 transports BIL from cytosol to extracellular region (blood) - Homo sapiens
[Reaction:R-HSA-9661432] BIL binds ALB - Homo sapiens
[BlackBoxEvent:R-HSA-9709883] BIL:ALB scavenges O2.- - Homo sapiens
[Reaction:R-HSA-9709885] BIL scavenges NO - Homo sapiens
[BlackBoxEvent:R-HSA-9709878] BIL translocates to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-400143] Fatty acid ligands activate PPARA - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年04月07日
literatureReference
[LiteratureReference:9708926] Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury
[LiteratureReference:9709924] Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease
[LiteratureReference:9708949] Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
[LiteratureReference:9709889] The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance
[LiteratureReference:9709910] Bilirubin, a Cardiometabolic Signaling Molecule
maxDepth
3
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Cytoprotection by HMOX1
orthologousEvent
[Pathway:R-MMU-9707564] Cytoprotection by HMOX1 - Mus musculus
[Pathway:R-RNO-9707564] Cytoprotection by HMOX1 - Rattus norvegicus
[Pathway:R-CFA-9707564] Cytoprotection by HMOX1 - Canis familiaris
[Pathway:R-BTA-9707564] Cytoprotection by HMOX1 - Bos taurus
[Pathway:R-SSC-9707564] Cytoprotection by HMOX1 - Sus scrofa
[Pathway:R-DRE-9707564] Cytoprotection by HMOX1 - Danio rerio
[Pathway:R-XTR-9707564] Cytoprotection by HMOX1 - Xenopus tropicalis
[Pathway:R-GGA-9707564] Cytoprotection by HMOX1 - Gallus gallus
[Pathway:R-DME-9707564] Cytoprotection by HMOX1 - Drosophila melanogaster
[Pathway:R-CEL-9707564] Cytoprotection by HMOX1 - Caenorhabditis elegans
[Pathway:R-DDI-9707564] Cytoprotection by HMOX1 - Dictyostelium discoideum
[Pathway:R-SPO-9707564] Cytoprotection by HMOX1 - Schizosaccharomyces pombe
[Pathway:R-SCE-9707564] Cytoprotection by HMOX1 - Saccharomyces cerevisiae
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2021年03月23日
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9713327] Somers, Julia, 2021年01月23日
[InstanceEdit:9956890] Hill, David P, 2025年06月16日
[InstanceEdit:9960546] Matthews, Lisa, 2025年07月14日
revised
[InstanceEdit:9766710] Rothfels, Karen, 2022年02月23日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9707564
summation
[Summation:9709923] Expression of heme oxygenase 1 (HMOX1) is regulated by vario...
updateTrackers
[UpdateTracker:9774858] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v80:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9911050] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v89:[updateContainedRLE, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-9711123] Cellular response to chemical stress
(hasEncapsulatedEvent)
[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
(updatedInstance)
[UpdateTracker:9774858] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v80:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9911050] Update Tracker - [Pathway:9707564] Cytoprotection by HMOX1 - v89:[updateContainedRLE, updateIndirectRLE]
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