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Signaling by FLT3 ITD and TKD mutants
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authored
[InstanceEdit:9706566] Rothfels, Karen, 2020年11月06日
created
[InstanceEdit:9703649] Rothfels, Karen, 2020年10月06日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12757954] BioModels Database:BIOMD0000000724
dbId
9703648
disease
[Disease:1500689] cancer
displayName
Signaling by FLT3 ITD and TKD mutants
edited
[InstanceEdit:9706566] Rothfels, Karen, 2020年11月06日
eventOf
[Pathway:R-HSA-9682385] FLT3 signaling in disease - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9695838] Ligand-independent dimerization of FLT3 mutants - Homo sapiens
[Reaction:R-HSA-9695834] Constitutive phosphorylation of FLT3 mutants - Homo sapiens
[Reaction:R-HSA-9695841] FLT3 mutant dimers bind GRB2 - Homo sapiens
[Reaction:R-HSA-9695845] FLT3 mutant dimers:GRB2 bind SOS1 - Homo sapiens
[Reaction:R-HSA-9695853] FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS - Homo sapiens
[Reaction:R-HSA-9698000] FLT3 mutants:GRB2 bind GAB2 - Homo sapiens
[Reaction:R-HSA-9698003] FLT3 mutants phosphorylate GAB2 - Homo sapiens
[Reaction:R-HSA-9698008] FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 - Homo sapiens
[Reaction:R-HSA-9698179] FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 - Homo sapiens
[Reaction:R-HSA-9698174] FLT3 mutants recruit PIK3CA through PIK3R1 - Homo sapiens
[Pathway:R-HSA-9702518] STAT5 activation downstream of FLT3 ITD mutants - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9703614] Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
[LiteratureReference:9683350] Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
[LiteratureReference:9691008] Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia
[LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
[LiteratureReference:9703638] The structural basis for autoinhibition of FLT3 by the juxtamembrane domain
[LiteratureReference:9703631] FLT3-ITD and its current role in acute myeloid leukaemia
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
[LiteratureReference:9703646] Point mutations in the FLT3 gene in AML
[LiteratureReference:9691847] Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
[LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
[LiteratureReference:9703523] AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
[LiteratureReference:9697800] Activation mechanisms of STAT5 by oncogenic Flt3-ITD
[LiteratureReference:9703528] FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
[LiteratureReference:9703627] FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation
[LiteratureReference:9697873] SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML
[LiteratureReference:9703594] Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia
[LiteratureReference:9703529] Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation
[LiteratureReference:9703597] Differential signaling of Flt3 activating mutations in acute myeloid leukemia: a working model
maxDepth
3
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Signaling by FLT3 ITD and TKD mutants
normalPathway
[Pathway:R-HSA-9607240] FLT3 Signaling
releaseDate
2020年12月08日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9706568] Kazi, Julhash U, 2020年11月06日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9703648
summation
[Summation:9703644] FLT3 is subject to internal tandem duplications (ITDs) of le...
Referrals
(hasEvent)
[Pathway:R-HSA-9682385] FLT3 signaling in disease
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