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Phosphorylated FLT3 fusions bind GRB2 Show undefined attributes

authored

[InstanceEdit:9706566] Rothfels, Karen, 2020年11月06日

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9703431] Rothfels, Karen, 2020年10月06日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9703442

disease

[Disease:1500689] cancer

displayName Phosphorylated FLT3 fusions bind GRB2

edited

[InstanceEdit:9706566] Rothfels, Karen, 2020年11月06日

eventOf

[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens

followingEvent

inferredFrom

[Reaction:R-MMU-9604768] Active Flt3 dimer binds Grb2 - Mus musculus

input

isChimeric false

isInDisease true

isInferred true

literatureReference

[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Phosphorylated FLT3 fusions bind GRB2

output

[Complex:R-HSA-9703378] p-Y FLT3 fusion dimers:GRB2 [cytosol]

precedingEvent

[Reaction:R-HSA-9703437] FLT3 fusion dimers autophosphorylate - Homo sapiens

releaseDate 2020年12月08日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9706568] Kazi, Julhash U, 2020年11月06日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9703442

summation

[Summation:9703420] FLT3 fusion proteins may signal through the PI3K/AKT and MAP...

Referrals

(hasEvent)

[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins

(precedingEvent)

(inferredTo)

[Reaction:R-MMU-9604768] Active Flt3 dimer binds Grb2

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