Reactome Pathway Database

Schema > Reaction > Entries

FLT3 fusions phosphorylate GAB2 Show undefined attributes

authored

[InstanceEdit:9706566] Rothfels, Karen, 2020年11月06日

catalystActivity

[CatalystActivity:9703426] protein tyrosine kinase activity of p-Y FLT3 fusions:GRB2:GAB2 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9703431] Rothfels, Karen, 2020年10月06日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9703438

disease

[Disease:1500689] cancer

displayName FLT3 fusions phosphorylate GAB2

edited

[InstanceEdit:9706566] Rothfels, Karen, 2020年11月06日

eventOf

[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens

followingEvent

[Reaction:R-HSA-9703439] FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

FLT3 fusions phosphorylate GAB2

output

precedingEvent

[Reaction:R-HSA-9703440] FLT3 fusions:GRB2 bind GAB2 - Homo sapiens

releaseDate 2020年12月08日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9706568] Kazi, Julhash U, 2020年11月06日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9703438

summation

[Summation:9703418] GAB2 is presumed to be phosphorylated downstream of active F...

Referrals

(precedingEvent)

[Reaction:R-HSA-9703439] FLT3 fusions recruit PIK3R1 through phosphorylated GAB2

(hasEvent)

[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins

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