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Schema
>
DefinedSet
>
Entries
alectinib resistant ALK mutants [plasma membrane]
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compartment
[Compartment:876] plasma membrane
consumedByEvent
[FailedReaction:R-HSA-9700656] alectinib resistant ALK mutants don't bind alectinib - Homo sapiens
created
[InstanceEdit:9700562] Rothfels, Karen, 2020年09月16日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9700560
disease
[Disease:1500689] cancer
displayName
alectinib resistant ALK mutants [plasma membrane]
hasMember
[Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9714056] ALK I1171S dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700519] ALK I1171T dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700000] ALK F1174C dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9715315] ALK V1180L dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700520] ALK L1196M dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9701834] ALK G1202R dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9715310] ALK S1206C dimer [plasma membrane] - Homo sapiens
inDisease
true
literatureReference
[LiteratureReference:9700317] ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression
[LiteratureReference:9711845] Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib
[LiteratureReference:9713876] Anaplastic Lymphoma Kinase (ALK) Kinase Domain Mutation Following ALK Inhibitor(s) Failure in Advanced ALK Positive Non-Small-Cell Lung Cancer: Analysis and Literature Review
[LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer
[LiteratureReference:9713982] Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden
[LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib
[LiteratureReference:9717278] Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma
maxDepth
3
modified
[InstanceEdit:9717350] Rothfels, Karen, 2021年03月08日
name
alectinib resistant ALK mutants
schemaClass
DefinedSet
species
[Species:48887] Homo sapiens
stId
R-HSA-9700560
Referrals
(input)
[FailedReaction:R-HSA-9700656] alectinib resistant ALK mutants don't bind alectinib
(diseaseEntity)
[EntityFunctionalStatus:9714044] loss_of_function of alectinib resistant ALK mutants [plasma membrane]
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