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Entries
Active ALK binds SHC1
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authored
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9700152] Rothfels, Karen, 2020年09月14日
dbId
9700154
displayName
Active ALK binds SHC1
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent
[Reaction:R-HSA-9700175] Active ALK phosphorylates SHC1 - Homo sapiens
input
[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane]
[DefinedSet:R-HSA-1169480] SHC1-2,SHC1-3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9699627] ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth
[LiteratureReference:9699620] ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
[LiteratureReference:9667905] Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase
[LiteratureReference:9699630] Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway
[LiteratureReference:201497] Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells
[LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Active ALK binds SHC1
orthologousEvent
[Reaction:R-GGA-9700154] Active ALK binds SHC1 - Gallus gallus
[Reaction:R-SSC-9700154] Active ALK binds SHC1 - Sus scrofa
[Reaction:R-BTA-9700154] Active ALK binds SHC1 - Bos taurus
[Reaction:R-CFA-9700154] Active ALK binds SHC1 - Canis familiaris
[Reaction:R-RNO-9700154] Active ALK binds SHC1 - Rattus norvegicus
[Reaction:R-MMU-9700154] Active ALK binds SHC1 - Mus musculus
output
[Complex:R-HSA-9699970] Active ALK:SHC1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9700154
summation
[Summation:9700153] SHC1 is recruited to the full-length ALK receptor after acti...
updateTrackers
[UpdateTracker:9853199] Update Tracker - [Reaction:9700154] Active ALK binds SHC1 - v87:[addLiteratureReference, add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9853199] Update Tracker - [Reaction:9700154] Active ALK binds SHC1 - v87:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)
[Reaction:R-HSA-9700175] Active ALK phosphorylates SHC1
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