Reactome Pathway Database

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Active ALK binds PLCG1 Show undefined attributes

authored

[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日

category binding

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9700150] Rothfels, Karen, 2020年09月14日

dbId 9700149

displayName Active ALK binds PLCG1

edited

[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日

eventOf

[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens

followingEvent

[Reaction:R-HSA-9700171] Active ALK phosphorylates PLCG1 - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

Active ALK binds PLCG1

orthologousEvent

output

[Complex:R-HSA-9699982] Active ALK:PLCG1 [plasma membrane]

precedingEvent

[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens

previousReviewStatus [ReviewStatus:9821384] two stars

releaseDate 2021年06月09日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9700149

summation

[Summation:9700148] Based on studies with the oncogenic NPM-ALK fusion, ALK is p...

updateTrackers

[UpdateTracker:9853234] Update Tracker - [Reaction:9700149] Active ALK binds PLCG1 - v87:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9853234] Update Tracker - [Reaction:9700149] Active ALK binds PLCG1 - v87:[addLiteratureReference, add_removeInput, modifyText]

(hasEvent)

[Pathway:R-HSA-201556] Signaling by ALK

(precedingEvent)

[Reaction:R-HSA-9700171] Active ALK phosphorylates PLCG1

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