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Search ...
Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
FLT3 R595_L601dup [plasma membrane]
Show undefined attributes
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compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-9696074] FLT3 R595_L601dup dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9696074] FLT3 R595_L601dup dimer [plasma membrane] - Homo sapiens
created
[InstanceEdit:9696040] Rothfels, Karen, 2020年07月17日
crossReference
[DatabaseIdentifier:11944921] Mondo:0018874
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:9832470] COSMIC:COSV54045432
dbId
9696032
deleted
[Deleted:9832476] Deletion of instance: 9696048
disease
[Disease:1500689] cancer
[Disease:9630839] acute myeloid leukemia
displayName
FLT3 R595_L601dup [plasma membrane]
endCoordinate
993
hasModifiedResidue
[FragmentInsertionModification:9696029] Insertion of residues 595 to 601 at 602 from UniProt:P36888 FLT3
inDisease
true
literatureReference
[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
[LiteratureReference:9649425] Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
[LiteratureReference:9696007] FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth
1
memberOf
[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens
[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified
[InstanceEdit:9832472] Orlic-Milacic, Marija, 2023年04月01日
name
FLT3 R595_L601dup
ITD3
N51
W51
referenceEntity
[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-9696032
startCoordinate
27
updateTrackers
[UpdateTracker:9905376] Update Tracker - [EntityWithAccessionedSequence:9696032] FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]
Referrals
(updatedInstance)
[UpdateTracker:9905376] Update Tracker - [EntityWithAccessionedSequence:9696032] FLT3 R595_L601dup [plasma membrane] - v85:[addLiteratureReference, modifyName]
(replacementInstances)
[Deleted:9832476] Deletion of instance: 9696048
(hasMember)
[DefinedSet:R-HSA-9699540] tandutinib-sensitive FLT3 mutants [plasma membrane]
[CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)
[Complex:R-HSA-9696074] FLT3 R595_L601dup dimer [plasma membrane]
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