Reactome Pathway Database

Schema > Polymerisation > Entries

CASP4 dimerizes Show undefined attributes

authored

[InstanceEdit:9947804] Shamovsky, Veronica, 2025年05月14日

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9686268] Shamovsky, Veronica, 2020年04月29日

dbId 9686271

displayName CASP4 dimerizes

edited

[InstanceEdit:9963520] Shamovsky, Veronica, 2025年08月14日

eventOf

[Pathway:R-HSA-9948001] CASP4 inflammasome assembly - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-9947861] CASP4 autocatalysis on LPS micelles - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

CASP4 dimerizes

orthologousEvent

output

[Complex:R-HSA-9686270] 2xCASP4:LPS micelles [cytosol]

precedingEvent

[Reaction:R-HSA-9686096] CASP4 binds LPS micelles - Homo sapiens

regulatedBy

[NegativeRegulation:9953129] Negative regulation by 'CASP4:SERPINB1 [cytosol]'

regulationReference

[RegulationReference:9953127] Negative regulation by 'CASP4:SERPINB1 [cytosol]' SERPINB1-mediated checkpoint of inflammatory caspase activation

releaseDate 2025年09月18日

releaseStatus NEW

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9963135] Shi, Xuyan, 2025年08月12日

schemaClass Polymerisation

species

[Species:48887] Homo sapiens

stId R-HSA-9686271

summation

[Summation:9686269] Sensing of cytoplasmic lipopolysaccharide (LPS) by caspase-4...

Referrals

(hasEvent)

[Pathway:R-HSA-9948001] CASP4 inflammasome assembly

(precedingEvent)

[BlackBoxEvent:R-HSA-9947861] CASP4 autocatalysis on LPS micelles

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