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Schema
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FailedReaction
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Entries
Sorafenib-resistant PDGFR mutants don't bind sorefenib
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authored
[InstanceEdit:9677035] Rothfels, Karen, 2020年02月25日
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9674407] Rothfels, Karen, 2020年01月13日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9674414
disease
[Disease:1500689] cancer
displayName
Sorafenib-resistant PDGFR mutants don't bind sorefenib
edited
[InstanceEdit:9677035] Rothfels, Karen, 2020年02月25日
entityFunctionalStatus
[EntityFunctionalStatus:9674402] loss_of_function of sorafenib-resistant PDGFR mutants [plasma membrane]
eventOf
[Pathway:R-HSA-9674404] Sorafenib-resistant PDGFR mutants - Homo sapiens
input
[ChemicalDrug:R-ALL-9657029] sorafenib [cytosol]
[DefinedSet:R-HSA-9673718] sorafenib-resistant PDGFR mutants [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9671429] Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors
[LiteratureReference:9673492] A novel FIP1L1-PDGFRA mutant destabilizing the inactive conformation of the kinase domain in chronic eosinophilic leukemia/hypereosinophilic syndrome
[LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Sorafenib-resistant PDGFR mutants don't bind sorefenib
normalReaction
[Reaction:R-HSA-9674095] PDGFRs bind type II TKI
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9676030] Ip, Carman K M, 2020年02月06日
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9674414
summation
[Summation:9674412] Sorafenib has broader effectiveness against many imatinib-re...
Referrals
(hasEvent)
[Pathway:R-HSA-9674404] Sorafenib-resistant PDGFR mutants
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